Kingsford & Lee publish paper with new method for HLA typing
Associate Professor & Lane Fellow Heewook Lee have published a paper in . The paper discusses the importance of accurate typing of human leukocyte antigen (HLA). HLA genes play important roles in immune responses and disease genesis. Previously available computational methods are database-matching approaches and their outputs are inherently limited by the completeness of already known types, making them unsuitable for discovery of novel alleles. Kingsford and Lee have developed a graph-guided assembly technique for classical HLA genes, which can construct allele sequences given high-coverage whole-genome sequencing data. Their method delivers highly accurate HLA typing, comparable to the current state-of-the-art methods.
To read more about their new method, follow this